The Insulin Magnesium Story
Magnesium is necessary for both the action
of insulin and the manufacture of insulin.
Magnesium is a basic building block to life and is present in ionic form throughout the full landscape of human physiology. Without insulin though, magnesium doesn’t get transported from our blood into our cells where it is most needed. When Dr. Jerry Nadler of the Gonda Diabetes Center at the City of Hope Medical Center in Duarte, California, and his colleagues placed 16 healthy people on magnesium-deficient diets, their insulin became less effective at getting sugar from their blood into their cells, where it’s burned or stored as fuel. In other words, they became less insulin sensitive or what is called insulin resistant. And that’s the first step on the road to both diabetes and heart disease.
Insulin is a common denominator, a central figure in life as is magnesium. The task of insulin is to store excess nutritional resources.This system is an evolutionary development used to save energy and other nutritional necessities in times (or hours) of abundance in order to survive in times of hunger. Little do we appreciate that insulin is not just responsible for regulating sugar entry into the cells but also magnesium, one of the most important substances for life. It is interesting to note here that the kidneys are working at the opposite end physiologically dumping from the blood excess nutrients that the body does not need or cannot process in the moment.
Controlling the level of blood sugars is only one of the many functions of insulin.
Insulin plays a central role in storing magnesium but if our cells become resistant to insulin, or if we do not produce enough insulin, then we have a difficult time storing magnesium in the cells where it belongs. When insulin processing becomes problematic magnesium gets excreted through our urine instead and this is the basis of what is called magnesium wasting disease.
There is a strong relationship between magnesium and insulin action.
Magnesium is important for the effectiveness of insulin. A reduction
of magnesium in the cells strengthens insulin resistance. [1],[2]
Low serum and intracellular magnesium concentrations are associated with insulin resistance, impaired glucose tolerance, and decreased insulin secretion. [3],[4],[5] Magnesium improves insulin sensitivity thus lowering insulin resistance. Magnesium and insulin need each other. Without magnesium, our pancreas won’t secrete enough insulin–or the insulin it secretes won’t be efficient enough–to control our blood sugar.
Magnesium in our cells helps the muscles to relax but if we can’t store magnesium because the cells are resistant then we lose magnesium which makes the blood vessels constrict, affects our energy levels, and causes an increase in blood pressure. We begin to understand the intimate connection between diabetes and heart disease when we look at the closed loop between declining magnesium levels and declining insulin efficiency.
Though it would be a long stretch of the longest giraffe’s neck to compare insulin with chlorophyll we are walking a trail at the very nuclear core of life. It’s the magnesium trail and we find to our surprise that it takes us into intimate contact with the very structure and foundation of life. The dedication of this chapter is to the beauty of magnesium, to its meaning in life, in health and in medicine.
We were talking about chlorophyll and now insulin and putting magnesium in-between. Walking further along is the DHEA magnesium story and the DNA magnesium story. And then there is the cholesterol magnesium story. Every part of life is in love with magnesium except allopathic medicine which just cannot accept it in all its light, flame and beauty. Thousands of years ago the Chinese named it the beautiful metal and they were seeing something pharmaceutical medicine does not want to see for there is little money to be made from something so common.
In a study from Taiwan, the risk of dying
from diabetes was inversely proportional to
the level of magnesium in the drinking water.[6]
Dr. Jerry L. Nadler
Dr. Jerry Nadler of the Gonda Diabetes Center at the City of Hope Medical Center in Duarte, California, and his colleagues placed 16 healthy people on magnesium-deficient diets, their insulin became less effective at getting sugar from their blood into their cells, where it’s burned or stored as fuel. In other words, they became less insulin sensitive.
Insulin regulates cholesterol levels. There is a direct connection
between the level of cholesterol and the level of insulin.
Magnesium is necessary for both the action of insulin and the manufacture of insulin. Magnesium is a basic building block to life and is present in ionic form throughout the full landscape of human physiology. Without insulin though, magnesium doesn’t get transported from our blood into our cells where it is most needed.
Diabetes mellitus is associated with magnesium depletion, which in turn contributes to metabolic complications of diabetes including vascular disease and osteoporosis. Intracellular depletion is directly connected to the impaired ability of insulin to increase intracellular magnesium during insulin deficiency or insulin resistance. Magnesium deficiency per se has been reported to result in insulin resistance.
Insulin resistance and magnesium depletion result in a vicious cycle of worsening insulin resistance and decrease in intracellular Mg(2+) which limits the role of magnesium in vital cellular processes.[7] Magnesium is an important cofactor for enzymes involved in carbohydrate metabolism so anything threatening magnesium levels threatens overall metabolism. Large epidemiologic studies in adults indicate that lower dietary magnesium and lower serum magnesium are associated with increased risk for type 2 diabetes.[8],[9]
Redistribution of magnesium into cells may cause lower
magnesium levels in the serum. Insulin causes this effect.
Researchers at the Institute of Internal Medicine, University of Palermo wrote, “Intracellular magnesium concentration has also been shown to be effective in modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli. A poor intracellular Mg concentration, as found in noninsulin-dependent diabetes mellitus (NIDDM) and in hypertensive patients, may result in a defective tyrosine-kinase activity at the insulin receptor level and exaggerated intracellular calcium concentration.” [10]
The link between diabetes mellitus and magnesium deficiency
is well known. A growing body of evidence suggests that
magnesium plays a pivotal role in reducing cardiovascular
risks and may be involved in the pathogenesis of diabetes itself.
Dr. Jerry L. Nadler
Magnesium improves and helps correct insulin sensitivity, which is the fundamental defect that characterizes pre-diabetes, metabolic syndrome and even full blown diabetes and heart disease. An intracellular enzyme called tyrosine kinase requires magnesium to allow insulin to exert its blood-sugar-lowering effects. In several studies, daily oral magnesium supplementation substantially improved insulin sensitivity by 10% and reduced blood sugar by 37%.[11],[12] Magnesium also helps correct abnormal lipoprotein patterns. We would expect to find larger improvements in this increased insulin sensitivity if magnesium is supplemented in a correct way meaning through transdermal and oral methods combined using liquid magnesium chloride (magnesium oil) as compared to the very inefficient oral solid forms commonly used.
Improved insulin sensitivity from magnesium replacement can markedly reduce triglyceride levels.[13] Reduced triglyceride availability, in turn, reduces triglyceride-rich particles, such as very low-density lipoprotein (VLDL) and small low-density lipoprotein (small LDL), both of which are powerful contributors to heart disease. Magnesium supplementation can also raise levels of beneficial high-density lipoprotein (HDL).[14]
Insulin regulates intracellular magnesium levels via
activation of Na+/Mg2+ exchange. Insulin’s effect on Na/Mg
exchange may explain the low cellular magnesium levels
observed in vivo under hyperinsulinemic conditions.[15]
Magnesium is a necessary element for all living organisms both animal and plant. Chlorophyll is structured around a magnesium atom, while in animals, magnesium is a key component of cells, bones, tissues and just about every physiological process you can think of. Magnesium is primarily an intracellular cation; roughly 1% of whole-body magnesium is found extracellularly, and the free intracellular fraction is the portion regulating enzyme pathways inside the cells. Life packs the magnesium jealously into the cells, every drop of it is precious.
Add the story of red blood cells and hemoglobin, which replace the chlorophyll molecule’s magnesium center with ion to function for O2 and CO2 transport, but retains magnesium in other crucial roles, and we are on the essential axis of life that allopathic medicine can address with intensive magnesium therapies.
Magnesium improves insulin sensitivity thus lowering insulin resistance. Magnesium and insulin need each other. Without magnesium, our pancreas won’t secrete enough insulin–or the insulin it secretes won’t be efficient enough–to control our blood sugar. Insulin is a hormone. And like many hormones, insulin is a protein. Insulin is secreted by groups of cells within the pancreas called islet cells. Insulin is much more important and has many more functions then we realize. It regulates:
lifespan - Lower insulin levels equate to a longer life.
blood sugar
blood lipids
excess nutrients (from glucose, carbs and calories) and converts them to fat
builds muscle
stores protein
magnesium levels in our body
calcium levels in the body
retains sodium levels
cell division
growth hormone
liver functions
sex hormones, estrogen, progesterone, testosterone
cholesterol in the body
fat in our body
Magnesium is a cofactor for multiple enzymes involved in carbohydrate metabolism.[16] Adipocyte cells placed in low-magnesium media show reduction in insulin-stimulated glucose uptake.[17] Magnesium deficiency is associated with increased intracellular calcium levels, which may lead to insulin resistance. Low erythrocyte magnesium content increases membrane microviscosity, which may impair insulin interaction with its receptor.[18] Tyrosine kinase activity is decreased in muscle insulin receptors of rats fed a low-magnesium diet.[19] These findings indicate that magnesium deficiency directly affects insulin signaling.
When magnesium levels fall hypersecretion of adrenalin and insulin compensate. Their increased secretion help maintain the constancy of the levels in intracellular magnesium in the soft tissues. Plasma and intracellular magnesium concentrations are tightly regulated by insulin. In vitro and in vivo studies have demonstrated that insulin modulates the shift of magnesium from extracellular to intracellular space.
Dr. Ron Rosedale says that, “Insulin floating around in the blood causes plaque build-up. They didn’t know why, but we know that insulin causes endothelial proliferation. Every step of the way, insulin is causing cardiovascular disease. It fills the body with plaque, it constricts the arteries, it stimulates the sympathetic nervous system, it increases platelet adhesiveness and coaguability of the blood.”
[1] Paolisso G, Scheen A, D’Onofrio F, Lefebvre P: Magnesium and glucose homeostasis. Diabetologia 33:511–514, 1990[Medline]
[2] Nadler JL, Buchanan T, Natarajan R, Antonipillai I, Bergman R, Rude R: Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 21:1024–1029, 1993
[3]Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, Hutchinson RG, Metcalf PA: Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid wall thickness: the ARIC study. J Clin Epidemiol 48:927–940, 1985
[4] Rosolova H, Mayer O Jr, Reaven GM: Insulin-mediated glucose disposal is decreased in normal subjects with relatively low plasma magnesium concentrations. Metabolism 49:418–420, 2000[Medline]
[5] Resnick LM, Gupta RK, Gruenspan H, Alderman MH, Laragh JH: Hypertension and peripheral insulin resistance: possible mediating role of intracellular free magnesium. Am J Hypertens 3:373–379, 1990[Medline]
[7] Magnesium transport induced ex vivo by a pharmacological dose of insulin is impaired in non-insulin-dependent diabetes mellitus. Hua, H : Gonzales, J : Rude, R K Magnes-Res. 1995 Dec; 8(4): 359-66
[8] Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB: Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care 27:134–140, 2004
[9] Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL: Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study. Arch Intern Med 159:2151, 1999
[10] Mol Aspects Med. 2003 Feb-Jun;24(1-3):39-52. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X.Barbagallo M, Dominguez LJ, Galioto A, Ferlisi A, Cani C, Malfa L, Pineo A, Busardo’ A, Paolisso G. Institute of Internal Medicine and Geriatrics, University of Palermo, Via F Scaduto 6/C, Palermo, Italy. mabar@unipa.it
[11] Guerrero-Romero F, Tamez-Perez HE, Gonzalez-Gonzalez G et al. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004 Jun;30(3):253-8.
[12] Rodriguez-Moran M and Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003 Apr;26(4):1147-52.
[13] Yokota K, Kato M, Lister F, et al. Clinical efficacy of magnesium supplementation in patients with type 2 diabetes. J Am Coll Nutr. 2004 Oct;23(5):506S-9S.
[14] Rasmussen HS, Aurup P, Goldstein K, et al. Influence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo controlled study. Arch Intern Med. 1989 May;149(5):1050-3.
[15] Am J Hypertens (2002) 15, 104A–104A; doi:S0895-7061(02)02558-X
P-207: Insulin regulates human erythrocyte Na+/Mg2+ exchange. Ana Ferreira1, Jose R. Romero1 and Alicia Rivera. Pathology, Harvard Medical School; Medicine, Harvard Medical School, Boston, MA, United States
[16] Paolisso G, Scheen A, D’Onofrio F, Lefebvre P: Magnesium and glucose homeostasis. Diabetologia 33:511–514, 1990[Medline]
[17] Kandeel FR, Balon E, Scott S, Nadler JL: Magnesium deficiency and glucose metabolism in rat adipocytes. Metabolism 45:838–843, 1996[Medline]
[18] Tongyai S, Rayssiguier Y, Motta C, Gueux E, Maurois P, Heaton FW: Mechanism of increased erythrocyte membrane fluidity during magnesium deficiency in weanling rats. Am J Physiol 257:C270–C276, 1989
[19] Suarez A, Pulido N, Casla A, Casanova B, Arrieta FJ, Rovira A: Impaired tyrosine-kinase activity of C
Hi,
Very interesting info. Good research info also.
Where does one buy magnesium chloride in Canada, more specifically northern ontario.
How does magnesium oxyde, magnesium chelate HvP, and magnesium citrate work in one’s body.
Thank you for your response.
Can you explain how this can affect someone (like myself) who has type 1 diabetes?
My pancreas doesn’t produce insulin, so how can Magnesium supplementation help me.
By the way, i have never been told any of this information by any of my diabetic doctors.
Also, i forgot to mention that i have read elsewhere that supplementing with magnesium should be done with extra calcium and zinc as magnesium alone will deplete these other 2 minerals. Can you comment on that also please.
Hi Graham,
Even type one diabetics suffer with insulin resistance and can benefit from magnesium use. Now there is even a condition called “double diabetes” where the symptoms of both type one and type two diabetes occur together. Have you seen our new diabetes site? Take a look for more information at: http://diabetic.imva.info/ It is representative of a great deal of information valuable to both types of diabetes, and that is in the new book “New Paradigms in Diabetic Care” available at: http://publications.imva.info/
For example, both types of diabetics suffer from the same complications. Do you know how fluoride in your drinking water can cause greater kidney problems for diabetics and must be avoided? No doctor will tell you about this either!
Magnesium can help to stabilize blood sugar in type one’s, can moderate blood pressure, and can have a great impact in preventing or stopping peripheral neuropathy. Magnesium may even help to lower insulin needs, as may use of nascent iodine. Magnesium can prevent some of the heart problems often experienced by type one diabetics, as well as type two diabetics. The information is relevant to both types of diabetics. Even going on a low carbohydrate diet will impact your condition and reduce your insulin needs and the less we have to take of this synthetic insulin, the better off our bodies and our health will be.
The American Diabetes Association, despite all of the evidence of magnesium’s impact on diabetes, still will not recommend anything but an increase in our diets of magnesium. The evidence that over 80% of diabetics are not getting enough magnesium from our diets does not seem to be enough for the ADA to get the ball rolling . While they can insist that all diabetics need to be on statins, they simply will not recommend magnesium. Perhaps because magnesium is not so tied to the pharmaceutical industry who they prefer to back. Magnesium is so much safer!
So take heed. Type one diabetics need magnesium as much or more than type two diabetics. Both should be supplementing with magnesium every single day!! Even if we increased magnesium in our diets, due to depletion in our soils, it is almost impossible to get adequate amounts of magnesium.
Get some magnesium oil from LL’s Magnetic Clay: http://www.magneticclay.com/
and start using it today.
I, too, am a type one diabetic, and I only wish I had known years ago, what I now know because of my work with Dr. Sircus. http://diabetic.imva.info/
Claudia French RN, LPHA
Assistant Director, IMVA
This an interesting article, but, like many that you find online, it lacks a specific recommendation. I am a healthy 190 lb male. How much MgCL2 do I need per day? Should it be taken with food? How would this dosage change if I was a Type II diabetic?
While I’m on the topic, why the Chloride? Does the Citrate work as well? I know enough to avoid the Carbonate.
Thanks in advance.
Kyle,
Keep reading! There is a tremendous amount of information available on this site with most of the answers to your questions. If you can’t find them on the site they will be in the books available on magnesium. Dr Sircus has prepared an amazing amount of information that he has freely given to people searching here.
To get you started here is an essay on why magnesium chloride is recommended over other forms of magnesium.
Claudia French RN, LPHA
Assistant Director, IMVA
Dear Sir/Madam
As a diet controlled diabetic – how do I ensue that I get the required amount of Magnesium. What foods contain this metal which I thought was bad for you? Surely the medical profession as a whole know about this
relatonship.
Yours
Peter Wright
Peter,
You need to read Dr. Sircus’ books for the information you want. Magnesium is probably the most important mineral in our bodies and it definitely is for diabetes. Look at our other sites for lots of info.
At the top of tis screen you will see links to many other essays, and at the publlication site http://publications.imva.info/ you can find many books and e-books on magnesium and our book on diabetes: New Paradigms in Diabetic Care.
As a diabetic myself, I am sorry to tell you that the medical profession is not fully aware of the relationship between magnesium and diabetes. Never once in 40 years of having this disease has any doctor even mentioned the need for magnesium to me. And have not properly tested for it either!
Today our soils are depleted and even our foods don’t contain adequate magnesium, we would have to eat very large amounts to get adequate daily supplies. Get some magnesium oil and use it daily.
Sincerely,
Claudia French RN, LPHA
Can you tell me the difference between using Mag Chloride and Mag Sulfide(epsom salts). Will epsom salt also increase Mag levels in the body?
thanks
Lois,
Epsom salts (magnesium sulfate) will raise magnesium levels, but research has shown that the levels of magnesium in your body from bathing in epsom salts do not last as long as from magnesium chloride. Magnesium Chloride has been found to be the safer type of magnesium by Jean Durlach, renowned magnesium researcher.
Please read the information on the MagnesiumforLife site for more information.
Sincerely,
Claudia French RN, LPHA
After learning the topic Magnesium for life ,it’s a very attractive medical information.It has a host of range in metabolism for the body,especially in the diabetic care.But in all diabetes treatment, why didn’t the authors aid Magnesium as and main adjuvant treatment ? “in several studies,daily oral Mag supplementation substantially improved insulin sensitivity by 10% an reduced blood sugar by 37%”
Thanks
Que dodieu
Magnesium Chloride is commonly found locally in “ice melt” in 50 pound bags for under $20. How many pounds of ice melt should be mixed in my bath for diabetes?
We advise being very careful buying what is described as ice melt. Many of these are formulated with proprietary ingredients for hastening the melting of ice and we have learned that some of these ingredients are listed as cancer causing. That’s why IMVA only recommends the most pure source of magnesium chloride in Ancient Minerals Magnesium Oil or flakes. There is no risk of contamination from harmful substances which may not be true in the generally available flakes or salts. If you trust your source or don’t mind taking a chance, you can use magnesium chloride in a pinch at the same rate recommended by Dr. Sircus in his writings….about 1-2 lb per bath. But the purity of Ancient Minerals Magnesium Oil or Bath Flakes cannot be surpassed.
Sincerely,
Claudia French
IMVA
It is amazing, all these millions of letters (abc’s), sentences, phrases, etc, etc, etc. and they do not answer to your one single question, what are the is the dosage or instruction, for that you have to continue suffering from cancer, having to spend on the books to make rich this so called Doctor of mercy, it sound as cruel as what they attack and condemn.
They have the same credibility as the rest of the bandits of the Pharmaceutical labs, Doctors that if they know the answer and they let this happening and all that are making money with the health and suffering of the sick people, it is a case for God.
I stop reading when I recognize the same trick of the scam articles you find every where.
I agree with Luis to a point.
That is a pattern to be careful about and one I watch for myself.
However if one is to just arbitrarily or randomly select data or information about such an important topic it can be almost useless if not dangerous.
The possible interactions with all other symptoms, diseases and medicine’s is phenomenal in size.
I have been studying and researching magnesium for over 10 years now and at one point every waking minute of energy I had when I was quite ill.
Along time before I heard of Dr Sircus or any other Dr referring to magnesium in a positive accurate light.
I went way back to the early 1930;s medical reports to find it first then Linus Pauling someone I studied in high school.
I found out that most modern medical records and doctors have removed, forgotten or just plain ignored magnesium. Possibly because it was not marketable or patentable.
The first item any medical emergency worker will try to get in your system in an emergency today is magnesium sulfate or a bicarbonate drip.Who cares why really that ignorance proved to me they were wrong or corrupt.
And now several people are being jailed and persecuted or prosecuted for any reference to any natural ingredient.
If you want to be careful fine and critical fine I encourage but to be lazy you do so at your own peril. Even after I discovered the right type of magnesium I had to personally discover the righ ta mount and the right application.
So if you want to listen to me without any effort or research on your part go ahead but its at your risk and peril.
I will never take oxide or citrate(their both laxatives and industrial and will harm you with long use) either a malate or taurate 500mg to a gram (weaning up to 500mg or a gram daily after six to eight weeks depending on your illnes) and also definitely a magnesium oil on my skin in lymph node areas.You can not just jump into this that would be foolish you must wean and test yourself as you go. You will have herxheimer effects and it will be very difficult.
If anyone is reading this and thinking of following what I wrote ……Think again. Research it yourself only trust yourself. And that statement has nothing to do with the validity of what I said.
Yes go ahead and read what Dr Sircus wrote. Verify and learn every medical term he uses, thats how I started and only when you understand those medical terms go back and read all you can on magnesium.
I did find the right magnesium distribution system and have greatly reduced debilitating effects and Magnesium has made my life bearable again. However I have no idea what it will do for anyone else without doing the same type of research on them.
I wish you all good luck, you are highly unlikely to find facts and truth and highly unlucky to be able to decipher all of it but it will make you more informed and thus give you a small chance to recover.
No one here ever mentioned Nigari, which is much pure Magnesium Chloride to the Ancient Minerals Magnesium (from the specification sheet numbers that I used to compare them).
Nigari is made for food additives, it can be diluted in pure water for drinking water usage, the result is to help you clean your body system so as to help you loose weight, this has been used and proved in Japan for years. And many other benefits…
Hi Christine,
Nigari is a fine source for magnesium chloride as long as the nigari obtained is not made of other substances (some are calcium and not magnesium). Haveing used nigari myself, I found it much too watery for transdermal use. It just does not have the same consistency as magnesium oil, so is wasteful when using it transdermally or for massages.
After one year following the relationship between Mag and Insulin action which has persuaded me that magnesium and insulin are synergies,the presence of magnesium that increases insulin sensitivity and insulin enhances the penetration of magnesium into cells.
In addition, according to the American Heart Association, maqgnesium has been demonstrated to be effective in bringing down high blood pressure and Japenese researchers also said that Mag may play a pivotal role in relaxing the blood vessels,an effect generally proven to help lower blood pressure.
Patients with diabetes are often have hypertentions simultaneously,which offers a best prescription of the use of magnesium in those patients.
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